Myeloperoxidase (MPO) Antibodies Test
Pinpoint autoimmune triggers behind your inflamed blood vessels.
The myeloperoxidase (MPO) antibodies test is used to detect autoantibodies directed against myeloperoxidase, an enzyme found in certain white blood cells. These antibodies are a type of antineutrophil cytoplasmic antibody (ANCA) and are strongly associated with small vessel vasculitis, including microscopic polyangiitis (MPA) and some cases of granulomatosis with polyangiitis (GPA). This test is typically requested when a patient has unexplained signs of systemic inflammation, such as kidney dysfunction, skin rashes, lung symptoms, or neuropathy, and there is a clinical suspicion of an autoimmune vasculitic process. It may also be used to monitor disease activity and guide treatment in patients with known ANCA-associated vasculitis.
Biomarkers
- Myeloperoxidase (MPO) antibodies
Why it matters
Detecting MPO antibodies can help confirm a diagnosis of ANCA-associated vasculitis, distinguish it from other inflammatory conditions, and inform timely immunosuppressive treatment to prevent organ damage. For patients already diagnosed, tracking MPO antibody levels can provide valuable insight into disease activity and response to therapy.
- Myeloperoxidase (MPO) antibodies
No special preparation required.
For blood tests, we recommend drinking plenty of water beforehand to ensure smooth sample collection. If you are taking any regular medication, continue to do so unless advised otherwise by your doctor.
Important Clinical Information:
This test is a screening tool to monitor and support your overall health. It does not replace your GP or consultant.
Always discuss your test results, especially any abnormal results, with your GP, who can interpret them in the context of your medical history and overall health.