Histone Antibodies Test
Pinpoint drug-induced lupus and autoimmune disease with clarity.
The Histone Antibodies Test detects autoantibodies directed against histone proteins, the basic building blocks of chromatin in cell nuclei. These antibodies are strongly associated with drug-induced lupus erythematosus (DILE), a lupus-like syndrome triggered by certain medications, and can also be found in idiopathic systemic lupus erythematosus (SLE) and other autoimmune connective tissue disorders. This test is typically requested when a patient presents with symptoms suggestive of lupus (such as joint pain, rash, fever, or serositis) and has a history of exposure to medications known to induce autoimmunity, or when differentiating between drug-induced and idiopathic lupus is clinically important. It may also be used as part of a broader autoantibody panel in the investigation of undifferentiated connective tissue disease.
The test is performed using an enzyme-linked immunosorbent assay (ELISA) or similar immunoassay technique to detect and quantify IgG antibodies against histones in a simple blood sample. Results are reported qualitatively or semi-quantitatively, with reference to established cut-off values.
Biomarkers
Autoantibodies
- Histone antibodies (IgG)
Why it matters
Histone antibodies are a key serological marker for drug-induced lupus, a condition that typically resolves after withdrawal of the offending medication. Identifying these antibodies can help distinguish drug-induced lupus from idiopathic SLE, guiding appropriate management and avoiding unnecessary long-term immunosuppression. In idiopathic SLE, histone antibodies may correlate with disease activity and specific clinical manifestations. Early recognition of drug-induced lupus allows for prompt discontinuation of the causative agent and resolution of symptoms, making this test a valuable tool in the differential diagnosis of lupus-like presentations.
Autoantibodies
- Histone antibodies (IgG)
No special preparation required.
For blood tests, we recommend drinking plenty of water beforehand to ensure smooth sample collection. If you are taking any regular medication, continue to do so unless advised otherwise by your doctor.
Important Clinical Information:
This test is a screening tool to monitor and support your overall health. It does not replace your GP or Consultant.
Always discuss your test results, especially any abnormal results, with your GP, who can interpret them in the context of your medical history and overall health.
Service Booking
Includes £15 phlebotomy fee
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