Antiphospholipid Antibody Screen | Blood Test
Uncover hidden antibody drivers of clotting and pregnancy loss.
The Antiphospholipid Antibody Screen is a blood test used to detect antibodies directed against phospholipids, the fat molecules that form cell membranes. These antibodies are associated with antiphospholipid syndrome (APS), an autoimmune condition that increases the risk of blood clots (thrombosis) and pregnancy complications such as recurrent miscarriage. This screen is typically requested for people with unexplained venous or arterial thrombosis, recurrent pregnancy loss, or certain autoimmune conditions such as lupus. It may also be used as part of a thrombophilia investigation or before starting hormonal therapy in those with a relevant clinical history.
Phospholipid Antibodies
- Total phospholipid antibodies: a broad screen for antibodies that target phospholipid structures. A positive result may prompt further testing for specific antiphospholipid antibodies (such as lupus anticoagulant, anticardiolipin, and anti-beta-2-glycoprotein I) to confirm or exclude antiphospholipid syndrome.
Why it matters
Identifying antiphospholipid antibodies can help explain otherwise unexplained blood clots or pregnancy losses and guide important clinical decisions. A positive screen does not always mean disease is present, so results are interpreted alongside your medical history and, where appropriate, repeat testing. Early detection supports timely specialist referral and personalised management to reduce the risk of future thrombotic or pregnancy-related complications.
Phospholipid Antibodies
- Total phospholipid antibodies
No special preparation required.
For blood tests, we recommend drinking plenty of water beforehand to ensure smooth sample collection. If you are taking any regular medication, continue to do so unless advised otherwise by your doctor.
Important Clinical Information:
This test is a screening tool to monitor and support your overall health. It does not replace your GP or consultant.
Always discuss your test results, especially any abnormal results, with your GP, who can interpret them in the context of your medical history and overall health.