Anti-gp210 Antibody Blood Test (Primary Biliary Cholangitis)

The anti-gp210 antibody blood test is used to detect a specific autoantibody associated with primary biliary cholangitis (PBC), a chronic autoimmune liver condition in which the small bile ducts within the liver are progressively damaged. This test is most useful for people who have already been diagnosed with PBC or who are being investigated for cholestatic liver disease, and it helps clinicians identify those at higher risk of more severe disease progression.

What it measures

• Anti-gp210 antibody (anti-gp210): an autoantibody directed against a protein component of the nuclear pore complex. Its presence is strongly associated with a more aggressive form of PBC, particularly with a higher risk of liver failure and progression to end-stage liver disease.

Who it is for

• Patients with confirmed or suspected primary biliary cholangitis.
• Individuals with unexplained cholestatic liver blood test abnormalities.
• Those being monitored for disease severity or risk stratification.
• People with other autoimmune conditions who develop liver-related symptoms.

Why it matters

Identifying anti-gp210 antibodies gives clinicians valuable prognostic information. In PBC, the presence of this antibody is linked to a greater likelihood of disease progression, including liver failure and the need for liver transplantation. Knowing this helps guide monitoring, treatment decisions, and referral for specialist hepatology care, supporting a more personalised approach to managing the condition.