Transferrin (TRF)

Transferrin (TRF) is the main protein responsible for transporting iron through the bloodstream to the bone marrow, where it is used to produce red blood cells. Measuring transferrin levels helps clinicians assess how well the body is managing and delivering iron, making it a valuable tool in the investigation of anaemia and iron disorders.

This test is typically requested when a patient has symptoms of anaemia such as fatigue, pallor, or breathlessness, or when iron deficiency or iron overload is suspected. It is also used to monitor conditions that affect iron metabolism, including chronic inflammation, liver disease, and nutritional deficiencies.

Biomarkers

Iron Transport
- Transferrin (TRF)

Transferrin is measured using an immunoturbidimetric assay, a well-established method for quantifying this transport protein in serum. Results are interpreted alongside other iron studies such as ferritin, serum iron, and transferrin saturation to build a complete picture of iron status.

Why it matters
Transferrin is a sensitive indicator of iron availability and can help distinguish between different types of anaemia. Low levels may suggest iron overload, inflammation, or liver dysfunction, while high levels can indicate iron deficiency or pregnancy. Understanding transferrin levels supports accurate diagnosis and effective management of iron-related conditions.