Sex Hormone-Binding Globulin Blood Test (SHBG)
Decode the hormone binding that shapes your fertility.
What’s tested
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Sex Hormone Binding Globulin (SHBG) is a liver-produced glycoprotein that binds to sex hormones, primarily testosterone and oestradiol, regulating the amount of free, biologically active hormone available to tissues. This test measures the level of SHBG in a simple blood sample, providing essential insight for anyone investigating fertility, hormonal imbalance, or conditions such as polycystic ovary syndrome (PCOS), hypogonadism, or thyroid dysfunction. It is particularly valuable when interpreted alongside total testosterone or oestradiol levels, as it helps calculate free hormone indices and clarifies whether symptoms are driven by altered binding capacity rather than absolute hormone production.
Biomarkers Included
Sex Hormone Binding Globulin
- Sex hormone binding globulin (SHBG)
Why it matters
SHBG levels directly influence how much testosterone and oestradiol remain unbound and active in the body. Abnormal SHBG can explain symptoms of androgen excess or deficiency, menstrual irregularities, subfertility, and metabolic conditions. Measuring SHBG gives clinicians a more accurate picture of hormonal status, guiding targeted treatment and improving outcomes in fertility and endocrine care.
No special fasting required. Drink plenty of water prior to your appointment for a smooth blood draw.
- Identification: Photo ID (Passport or Driving Licence) is only required if you need your report for official, employment, visa/travel, premarital, or Identity-Verified Certificate (IVS) purposes (not required for personal health & wellness testing).
This test provides an official, quality-assured laboratory report with reference ranges. These results are for clinical information and do not replace your GP or consultant. Always discuss abnormal results with your GP or specialist in the context of your medical history.
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