Hepatitis B Profile

The Hepatitis B Profile is a comprehensive blood test that screens for current or past infection with the hepatitis B virus (HBV) and assesses your immune status. It is suitable for anyone concerned about possible exposure, those planning to start antiviral treatment, individuals undergoing fertility or pre-operative screening, and people who want to confirm immunity following vaccination. The test examines five key markers that together provide a full picture of your hepatitis B status.

Hepatitis B surface antigen (HBsAg)
- Indicates current infection with hepatitis B virus. A positive result means the virus is present and you may be infectious to others.

Hepatitis B surface antibody (HBsAb)
- Shows whether you have protective immunity, either from successful vaccination or from recovery after past infection.

Hepatitis B e antigen (HBeAg)
- A marker of active viral replication. When present, it generally indicates higher infectivity.

Hepatitis B e antibody (HBeAb)
- Suggests that viral replication has slowed or stopped, often appearing as the immune system brings the infection under control.

Hepatitis B core antibody (HBcAb)
- Indicates past or ongoing exposure to the virus. It appears early in infection and remains detectable for life.

Together, these markers help distinguish between acute infection, chronic infection, resolved infection, and immunity from vaccination. The profile is particularly useful for healthcare workers, people born in regions where hepatitis B is common, and anyone who has had potential exposure through blood, sexual contact, or medical procedures.

Why it matters
Hepatitis B can remain silent for years while quietly damaging the liver. Early detection allows for monitoring, treatment where needed, and steps to protect others. Knowing your status also confirms whether you are protected, so you can take appropriate action with confidence.