fPSA (Free Prostate-Specific Antigen)
Measures free PSA levels alongside total PSA to provide additional clinical context for prostate assessment.
What’s tested
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Free Prostate-Specific Antigen (fPSA) is a specialised blood test used to refine prostate cancer risk assessment, particularly when total PSA is elevated but a digital rectal examination is normal. It measures the proportion of PSA that circulates unbound to proteins, helping clinicians distinguish between benign prostate conditions and prostate cancer. This test is typically requested for men with a total PSA between 4 and 10 ng/mL, where the free-to-total PSA ratio can improve diagnostic accuracy and reduce unnecessary biopsies.
The test is performed using a simple blood sample, with analysis conducted via immunoassay techniques. It is not a standalone screening tool but is used alongside total PSA and clinical findings to guide decision-making.
Biomarkers
Tumour Markers
- Free prostate-specific antigen (fPSA)
Why it matters
The free-to-total PSA ratio provides valuable information that can help avoid invasive procedures when the likelihood of cancer is low, while identifying men who may benefit from further investigation. By refining risk stratification, fPSA testing supports more informed and personalised prostate care.
No special fasting required. Drink plenty of water prior to your appointment for a smooth blood draw.
- Identification: Photo ID (Passport or Driving Licence) is only required if you need your report for official, employment, visa/travel, premarital, or Identity-Verified Certificate (IVS) purposes (not required for personal health & wellness testing).
- Exercise: Ideally avoid heavy gym workouts or cycling for 24 hours prior to testing (or let our phlebotomist note recent exercise on your record).
This test provides an official, quality-assured laboratory report with reference ranges. These results are for clinical information and do not replace your GP or consultant. Always discuss abnormal results with your GP or specialist in the context of your medical history.
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