Sickle Cell & Genotype Profiles
Sickle cell and genotype profiles are specialised blood tests that examine the haemoglobin genes you have inherited. They identify common variants such as sickle cell (HbS), haemoglobin C (HbC), and the thalassaemias, as well as determining your blood group. These tests are valuable for anyone planning a family, individuals of African, Caribbean, Mediterranean, Middle Eastern, or South Asian heritage, and those with a personal or family history of anaemia or abnormal haemoglobin. Understanding your genotype can provide clarity for reproductive decisions and help you take proactive steps for your health.
Comparing the available tiers allows you to choose the level of detail that best suits your circumstances. Whether you need a straightforward sickle status check, a comprehensive thalassaemia workup, or a full profile that includes blood grouping, each tier builds on the last to give you a complete picture. This structured approach ensures you receive accurate, clinically relevant information with the convenience of same-day results and no fasting required.
Sickle Cell Genotype (AA, AS, SS)
- Turnaround: Same Day
- Sample: Blood
- Fasting: No fasting required
- Biomarkers: 12 analysed
Sickle Cell Genotype Plus
- Turnaround: Same Day
- Sample: Blood
- Fasting: No fasting required
- Biomarkers: 19 analysed
Blood Group & Sickle Cell Genotype (AA, AS, SS)
- Turnaround: Same Day
- Sample: Blood
- Fasting: No fasting required
- Biomarkers: 14 analysed
Blood Group & Sickle Cell Genotype Plus
- Turnaround: Same Day
- Sample: Blood
- Fasting: No fasting required
- Biomarkers: 21 analysed
Biomarkers Analysed Comparison
Total 21 unique markers analysed. 12 Common 9 Differing| Biomarker Parameter |
Sickle Cell Genotype (AA, AS, SS)
£105.00
Standard
|
Sickle Cell Genotype Plus
£145.00
Plus Thalassaemia
|
Blood Group & Sickle Cell Genotype (AA, AS, SS)
£129.00
Plus Blood Group
|
Blood Group & Sickle Cell Genotype Plus
£170.00
Plus Blood Group & Thalassaemia
|
|---|---|---|---|---|
| General Biomarkers 21 markers | ||||
|
Genotype - AA,AS,AC, etc
|
||||
|
Genotype - HbA0
|
||||
|
Genotype - HbA1b
|
||||
|
Genotype - HbA1c
|
||||
|
Genotype - HbA2
|
||||
|
Genotype - HbC
|
||||
|
Genotype - HbD
|
||||
|
Genotype - HbF
|
||||
|
Genotype - HbS
|
||||
|
Genotype - Other variants (if present)
|
||||
|
Genotype - Sickle status
|
||||
|
β - Thalassaemia status (beta)
|
||||
|
Blood Group - ABO
Tier Difference
|
— | — | ||
|
Blood Group - RhD
Tier Difference
|
— | — | ||
|
Ferritin - Iron Storage
Tier Difference
|
— | — | ||
|
Red blood cells - HGB
Tier Difference
|
— | — | ||
|
Red blood cells - MCH
Tier Difference
|
— | — | ||
|
Red blood cells - MCV
Tier Difference
|
— | — | ||
|
Red blood cells - RBC
Tier Difference
|
— | — | ||
|
α - Thalassaemia status (alpha)
Tier Difference
|
— | — | ||
|
γ - Thalassaemia status (gamma if present)
Tier Difference
|
— | — | ||
Which Test Do I Need?
Which Sickle Cell & Genotype Profile is right for you?
Standard (£105.00): This tier provides a core haemoglobin genotype analysis. It identifies common variants including HbS (sickle), HbC, HbD, and other abnormal haemoglobins, and reports your sickle status (e.g. AA, AS, AC) and beta thalassaemia status. It is ideal for individuals who want a basic genetic screen, such as those with a known family history of sickle cell trait or disease, or anyone seeking preconception advice. No fasting is required and results are available the same day.
Plus Thalassaemia (£145.00): Building on the Standard tier, this profile adds a full red blood cell indices panel (RBC, HGB, MCV, MCH) and ferritin (iron storage), along with alpha, beta, and gamma thalassaemia status. This tier is suited for those with unexplained anaemia, a family history of thalassaemia, or individuals from regions where thalassaemia is more common. The additional blood count and iron studies help distinguish between thalassaemia trait and iron deficiency, providing a more comprehensive haematological assessment.
Plus Blood Group (£129.00): This tier combines the core genotype analysis of the Standard profile with blood group determination (ABO and RhD). It is an excellent choice for expectant mothers, individuals planning pregnancy, or anyone who needs to know their blood type for medical or personal reasons. It offers the same sickle and beta thalassaemia status as the Standard tier, plus the practical information of your blood group, all from a single blood sample.
Plus Blood Group & Thalassaemia (£170.00): This is the most comprehensive option, integrating all elements of the previous tiers. It includes the full genotype analysis, blood group (ABO and RhD), red blood cell indices, ferritin, and alpha, beta, and gamma thalassaemia status. It is recommended for individuals who want a complete picture of their haemoglobin genetics and blood type, particularly those with a family history of both sickle cell and thalassaemia, or couples seeking thorough preconception screening. This tier provides maximum diagnostic depth and peace of mind.
Clinical Recommendation
If you are simply seeking to know your sickle cell status or are considering starting a family, the Standard tier may be sufficient. However, if you have symptoms of anaemia, a family history of thalassaemia, or are of Mediterranean, Middle Eastern, or South Asian descent, the Plus Thalassaemia tier offers valuable additional insights. For those who also need blood group information, the Plus Blood Group tier is a practical choice. The Plus Blood Group & Thalassaemia tier is the most thorough and is advised for anyone wanting a complete genetic and haematological profile. All tests require no fasting and return same-day results, making them convenient and reliable.
Need personalised clinical guidance?
Our clinical laboratory team in London is available to discuss your testing requirements, pre-test preparation, and help you select the most suitable health profile.