Accurate. Reliable. Trusted.
When it comes to screening for sickle cell disease and beta-thalassaemia, accuracy is not optional; it is essential. That is why many leading laboratories, hospitals, and genetic counsellors rely on High Performance Liquid Chromatography (HPLC) as the gold standard for haemoglobin variant testing.
What is HPLC?
High Performance Liquid Chromatography (HPLC) is an advanced laboratory method that separates, identifies, and quantifies different types of haemoglobin in the blood. It provides a precise measurement of haemoglobin A, S, C, D, F, and other abnormal variants.
Why Choose HPLC for Sickle Cell and Thalassaemia?
Here’s why HPLC stands out:
1. Exceptional Accuracy
HPLC can detect even small percentages of abnormal haemoglobin types. This precision helps identify carriers (AS, AC) as well as those with full disease (SS, SC, beta-thalassaemia).
2. Early Detection
HPLC allows for early diagnosis in infants, children, and adults; critical for premarital screening or family planning.
3. Differentiates Haemoglobin Variants
Unlike simple tests or rapid kits, HPLC distinguishes between similar types (like HbS, HbC, HbD), which avoids false results that could lead to poor decisions about marriage or children.
4. Quantitative Results
HPLC provides exact percentages of each haemoglobin type, which is essential in detecting compound disorders (e.g. sickle beta-thalassaemia).
5. Internationally Recognised
HPLC is approved and recommended by organisations like the World Health Organization (WHO).
Why It Matters Before Marriage
For individuals from backgrounds with high sickle cell and thalassaemia prevalence, testing before marriage is a vital step. If both partners are carriers, there is a 25% chance with each pregnancy of having a child with sickle cell disease (SS).
Using HPLC gives couples the confidence that their results are trustworthy. It supports informed decision-making and protects future generations.
Our Lab Uses HPLC; Because You Deserve the Best
At our clinic, we use top-of-the-line HPLC equipment to ensure:
- Same-day or next-day results
- Confidential and professional handling
- Trusted interpretation
Whether you are planning a wedding or just curious about your status, don’t settle for guesswork. Use the best; use HPLC.
