Thrombophilia Panel 2

Service Description

PCR-hybridization: This test uses to detect 4 genetic variations associated with increased risk of blood clots. These are: - Factor II (G20210A) - Factor V (Leiden G1691A) - MTHFR (C677T) - GP1a Factor II (G20210A) is a genetic variation in the Factor II gene that results in higher levels of clotting Factor II in the blood. This variation has been associated with an increased risk of deep vein thrombosis, pulmonary embolism, and other thrombotic events. Factor V (Leiden G1691A) is a genetic variation in the Factor V gene that results in a mutated form of Factor V that is resistant to inactivation by protein C. This variation has been associated with an increased risk of deep vein thrombosis, pulmonary embolism, and other thrombotic events. MTHFR (C677T) is a genetic variation in the MTHFR gene that affects the production of the enzyme methylenetetrahydrofolate reductase, which is involved in the metabolism of the amino acid homocysteine. This variation can lead to elevated levels of homocysteine in the blood, which has been associated with an increased risk of cardiovascular disease and thrombotic events. GP1a (Glycoprotein Ib alpha) is a subunit of the GPIb-IX-V complex, a receptor complex found on the surface of platelets that plays a critical role in the process of platelet adhesion and aggregation, which is necessary for normal blood clotting. Variations in the GP1a gene can affect the function of the GPIb-IX-V complex and have been associated with an increased risk of bleeding disorders, such as Bernard-Soulier syndrome, as well as an increased risk of thrombotic events, such as deep vein thrombosis and myocardial infarction. Individuals with one or more of these genetic variations may have an increased risk of developing blood clots and bleeding disorders. This test is useful in identifying individuals who may be at increased risk, particularly in the context of other risk factors such as a personal or family history of blood clots, pregnancy, surgery, or immobility. Sample: BLOOD Results:2 weeks Phlebotomy fee: £15 (included in price)