Plasminogen Activator Inhibitor-1 |PAI-1

Service Description

Real-Time PCR: Plasminogen activator inhibitor-1 (PAI-1) is a protein that regulates the breakdown of blood clots in the body. The PAI-1 gene encodes for this protein and genetic variations in this gene can affect the levels and activity of PAI-1. The most well-known genetic variation in the PAI-1 gene is the 4G/5G polymorphism, which affects the promoter region of the gene. This variation involves either a deletion (4G) or an insertion (5G) of a guanine nucleotide in the promoter region of the PAI-1 gene. The 4G allele has been associated with higher levels of PAI-1 and increased risk of thrombotic events, such as deep vein thrombosis, pulmonary embolism, and stroke. It has also been linked to various cardiovascular diseases, including coronary artery disease and myocardial infarction. On the other hand, the 5G allele is associated with lower levels of PAI-1 and potentially a decreased risk of these conditions. However, it is important to note that the relationship between the PAI-1 4G/5G polymorphism and disease risk is complex and may be influenced by other factors such as age, gender, lifestyle factors, and other genetic variations. Genetic testing for the PAI-1 4G/5G polymorphism may be useful in identifying individuals who may be at increased risk of thrombotic events or cardiovascular diseases. Sample: BLOOD Results:2 weeks Phlebotomy fee: £15 (included in price)