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Glycoprotein Polymorphism GPIa

Understand your risk of platelet disorders, one gene at a time

  • 15 min
  • 125 British pounds
  • 305 Neasden Lane, London NW10 1QR, UK

Service Description

Glycoprotein polymorphism GPIa refers to genetic variations in the GPIa gene that encodes for the alpha 2 subunit of the GPIa/IIa complex, also known as integrin alpha 2 beta 1. This complex is a receptor on platelets that binds to collagen, which plays a crucial role in platelet adhesion and aggregation. One of the most common GPIa polymorphisms is the PlA1/PlA2 polymorphism, which involves a substitution of a leucine (Leu) for a proline (Pro) at position 33 of the GPIa protein. The PlA2 variant has been associated with increased platelet reactivity and a higher risk of thrombotic events such as myocardial infarction and stroke. However, not all studies have found a significant association between the PlA2 variant and cardiovascular disease. Other GPIa polymorphisms have also been identified, including the C807T and T1648C variants, which have been associated with platelet function and thrombotic risk in some populations. However, more research is needed to fully understand the clinical implications of these variations. Testing for GPIa polymorphisms can be useful in identifying individuals who may be at increased risk of thrombotic events and may benefit from targeted prevention strategies. Sample: BLOOD Results:2 weeks Phlebotomy fee: £15 (included in price)

Cancellation Policy

To cancel or schedule, please contact us 24 hours in advance

Contact Details

  • 305 Neasden Lane, London NW10 1QR, UK


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