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Apolipoprotein E (APO E) Polymorphism

Understand your risk of Alzheimer's disease, one gene at a time

  • 15 min
  • 125 British pounds
  • 305 Neasden Lane, London NW10 1QR, UK

Service Description

Apolipoprotein E (APOE) is a gene that provides instructions for making a protein that is involved in the transport and metabolism of cholesterol and other lipids in the body. APOE has several common polymorphisms, or variations, that affect its function. This test uses Real-Time PCR to detect the three most common APOE polymorphisms which are ε2, ε3, and ε4. These polymorphisms affect the structure of the APOE protein and can have different effects on lipid metabolism and risk for certain diseases. The ε3 allele is the most common variant and is considered to have a neutral effect on lipid metabolism and disease risk. The ε2 allele is associated with lower levels of low-density lipoprotein (LDL) cholesterol, but it is also associated with an increased risk for type 3 hyperlipoproteinemia, a rare lipid disorder. The ε4 allele is associated with higher levels of LDL cholesterol and an increased risk for cardiovascular disease, Alzheimer's disease, and other neurological disorders. Sample: BLOOD Results:2 weeks Phlebotomy fee: £15 (included in price)

Cancellation Policy

To cancel or schedule, please contact us 24 hours in advance

Contact Details

  • 305 Neasden Lane, London NW10 1QR, UK


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