AKT1 Deletion & Duplication
AKT1 Gene: Understand Your Cancer Risk.
Service Description
AKT1 gene mutations, including deletions or duplications, are significant because the AKT1 gene plays a critical role in regulating cell growth, proliferation, and survival. Alterations in this gene can lead to abnormal cell behavior, including uncontrolled growth that can contribute to cancer development. AKT1 Deletion: Deletion of parts or the entire AKT1 gene can disrupt the normal function of the AKT1 protein, leading to impaired signaling in pathways crucial for cell survival and proliferation. While deletions may potentially lead to loss of function, they are less common in cancer compared to activating mutations. AKT1 Duplication: Duplication of the AKT1 gene or regions of the genome that include AKT1 can lead to overexpression of the AKT1 protein. This increased AKT1 signaling can cause uncontrolled cell growth and survival, which is a hallmark of cancer development. The AKT1 gene is frequently mutated in cancers such as breast cancer, colorectal cancer, and lung cancer. A specific mutation known as AKT1 E17K (glutamic acid at position 17 is replaced with lysine) is common in certain cancers, leading to constitutive activation of the AKT1 protein. Sample: BLOOD (2 x EDTA) Results: 13 weeks Phlebotomy fee: £15 (included in price)
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Contact Details
305 Neasden Lane, London NW10 1QR, UK
02071268511
info@ejbio.co.uk