Adenosine Deaminase (ADA)

Service Description

Biomarker: ADA Sample: BLOOD Results: 2 HRS Phlebotomy: £0.00 ADA is an enzyme that plays a role in purine metabolism and the immune system. The ADA test measures the level of ADA in the blood, typically to diagnose or monitor certain medical conditions ADA deficiency is a rare genetic disorder that affects the immune system, specifically impairing the function of T and B lymphocytes. TEST SIGNIFICANCE 1. Severe Combined Immunodeficiency (SCID): ADA deficiency is a rare genetic disorder that leads to severe combined immunodeficiency (SCID), also known as the "bubble boy" disease. The ADA blood test can help diagnose ADA deficiency, which impairs the immune system's ability to fight infections. Early detection and treatment are crucial for individuals with SCID. 2. Tuberculosis (TB) Diagnosis: The ADA blood test can be helpful in the diagnosis of tuberculosis, particularly in cases of extrapulmonary tuberculosis (TB that affects parts of the body other than the lungs). Elevated ADA levels in body fluids, such as pleural fluid (fluid around the lungs) or cerebrospinal fluid (fluid around the brain and spinal cord), can be an indicator of TB infection. This test is often used when other diagnostic methods, such as culturing the TB bacteria, are inconclusive. SYMPTOMS OF ADA DEFICIENCY The symptoms of ADA deficiency can vary in severity and may include: -- Severe combined immunodeficiency (SCID): SCID, a condition characterized by a severely weakened immune system. Infants with ADA deficiency may experience recurrent and severe infections, such as pneumonia, meningitis, or bloodstream infections. -- Failure to thrive: Infants with ADA deficiency may have difficulty gaining weight and growing at a normal rate. -- Chronic diarrhoea: Persistent or chronic diarrhoea can be a symptom of ADA deficiency. -- Recurrent respiratory infections: Children with ADA deficiency may experience frequent respiratory infections, such as pneumonia or bronchitis. -- Skin rashes or infections: Skin problems, including rashes or infections, may occur in individuals with ADA deficiency. -- Developmental delays: In some cases, ADA deficiency can lead to developmental delays or intellectual disabilities.

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Contact Details

• 305 Neasden Lane, London NW10 1QR, UK

  02071268511

  info@ejbio.co.uk